Transcribing malignancy: transcription-associated genomic instability in cancer

genomic and epigenetic instability in colorectal cancer

abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...

breast cancer and paradigm of genomic instability

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Genomic Instability and Breast Cancer

MicroRNAs, Genomic Instability and Cancer

MicroRNAs (miRNAs) are small non-coding RNA transcripts approximately 20 nucleotides in length that regulate expression of protein-coding genes via complementary binding mechanisms. The last decade has seen an exponential increase of publications on miRNAs, ranging from every aspect of basic cancer biology to diagnostic and therapeutic explorations. In this review, we summarize findings of miRN...

Genomic Instability, Inflammation, and Cancer

Accumulating evidence supports that the inflammatory milieu plays a key role in the initiation and progression of epithelial cancer, the most characteristic example being that of ulcerative colitis which is associated with increased risk of colonic adenocarcinoma. Other less frequent and studied inflammatory lesions include asbestos-induced cellular damages, oral lichen planus (premalignant les...